Methuselah Foundation · Biomarker of Aging Consortium
Prizes, NASA, and how we agree to measure aging · Virginia
Levels of Longevity Map Dane explores
Dane Gobel is one of 100+ experts in the Live Beyond Project — a father & son quest for longevity.
Discover Live Beyond →Dane Gobel runs the Methuselah Foundation’s prize competitions — including a partnership with NASA — and works with the Biomarker of Aging Consortium, part of the group behind the Biomarkers of Aging conference at Harvard. He is also Dave Gobel’s son, which means he has spent most of his life inside a field that spent most of its life being laughed at.
That gives him an unusually long view. His verdict is that longevity research no longer feels like something gestating — it feels like something that has finally been born. His analogy is a teenager who has just passed their driving test: not yet an apartment in the city, but genuinely able to navigate the world.
He is careful about the framing everyone else fights over. He does not think aging is a disease. He thinks it is a hundred or more different things that can go wrong, conveniently bundled under one label — and that treating the label as a single target has been useful politically while remaining scientifically misleading.
He is also honest about where progress actually came from. The first ten years were brutal, though oddly low-risk, since everyone already assumed you were insane and any ground gained counted as a win. Regenerative medicine and 3D bioprinting made the field legible around 2010, because nobody objects to growing spare organs. The first gerotherapeutic startups followed in 2015 and 2016, and are only now reaching trials. And the first drug that genuinely moves healthspan at scale, he suspects, is a GLP-1 — which came from outside the longevity world entirely.
We met Dane twice: first in Virginia, on the same trip where we interviewed his father Dave, and again in Boston at the Biomarkers of Aging conference he helps organise. It was not lost on us. A father and son had travelled halfway around the world to interview a father and son who had built their working lives around the same question — one from the foundation and prize end, one from the measurement end.
“It doesn’t feel so much like a field that’s gestating. It feels like a field that’s finally been born.”
— Dane Gobel, Virginia
“Personally, I don’t think aging is a disease. I think it’s about a hundred different things or more that can go wrong — nicely wrapped up in this label called aging.”
Dane Gobel · Methuselah FoundationThe first ten years were extraordinarily hard. In some ways easy, because the risk was so low — everyone already thought you were insane.
Dane GobelNobody has any issue with generating organs from your own cells. Everyone would like to have more organs available.
Dane GobelThe first real longevity drug is probably something like a GLP-1 — and that didn’t come out of the longevity community at all.
Dane GobelBiotech is already an extraordinarily risky space. It doesn’t make any sense to be in there. And it worked well enough.
Dane GobelFrom our conversation in Virginia — the long view of a field he grew up inside, and where he thinks the real progress came from.
Startups founded in 2015 and 2016 are now entering or approaching clinical trials — and a biotech company usually needs a decade to get anywhere. What looked like stagnation was simply the length of the runway.
“Those early startups are on the cusp of doing it. It feels like it’s finally happening.”
Virginia · from the interviewNot the audacious claims — the practical ones. Regenerative medicine and 3D bioprinting gave the field something nobody could object to, and that opened the door for the stranger, more ambitious work behind it.
“It’s so easy to get your head around. It’s so fundamental.”
Virginia · from the interviewHe is refreshingly unbothered that the most consequential healthspan drug so far didn’t emerge from his own field. Metformin is probably geroprotective, he says, but the effect isn’t close to what a GLP-1 does.
“That popped out of nowhere, and I’m very happy that it exists.”
Virginia · from the interviewThe video interview is coming. Recorded interviews go live after the launch of the film & series Live Beyond.
Selected passages from our conversation with Dane Gobel — Virginia, June 2024. Lightly edited for readability.
Dane Gobel“What excites me most is that it doesn’t feel so much like a field that’s gestating. It feels like a field that’s finally been born. Sometimes I compare it to a kid who’s got their driver’s licence — they might not have an apartment in the city yet, but they’re learning how to navigate the world. It’s a real thing.”
Dane Gobel“In the early 2000s people started thinking about how you could deal with aging as if it’s a disease. Personally, I don’t think it’s a disease. I think it’s about a hundred different things or more that can go wrong, which is nicely wrapped up in this label called aging.”
Dane Gobel“The first ten years were extraordinarily hard. In some ways easy, because the risk was so low — everyone already thought you were insane. So if you could gain any ground, it was a win. You could do wild and crazy things. The stakes were low.”
Dane Gobel“Around 2010 there was really good work in regenerative medicine and 3D bioprinting, which paved the way from a startup perspective for the more audacious things the gerotherapeutic world wanted to do. Nobody has any issue with generating organs from your own cells — everything is so practical. Everyone would like to have more organs available. Then in 2015, 2016, the first batch of gerotherapeutic startups really got going. All of that takes a lot of time. A biotech startup takes a decade to get something where it needs to go — and those early startups are now in trials or about to be. It feels like it’s finally happening. I’m incredibly grateful for everything the community did to keep going.”
Dane Gobel“I think the first longevity drug is probably something like Wegovy or Mounjaro, honestly. People have talked for years about metformin being geroprotective, and I think it probably is — but the effects are not nearly as profound as a GLP drug. And that didn’t come out of the longevity community. It popped out of nowhere, and I’m very happy that it exists. My hope is that the next round is the kind of thing that also dramatically increases longevity, almost passively.”
Marek Piotrowski“Would you take these gene therapies? Would you be ready to do that?”
Dane Gobel“I got invited to participate in a clinical trial for follistatin, and I’ve been talking with some folks about doing a Klotho trial. Personally I think it’s very interesting, and I’d probably do it. I’d want to dig into it further — but there’s a good chance I’d do it. I don’t have any personal objection to it at all. I think it’s cool.”
More passages from the full interview will be published here.
Dane works across Creating the Movement and Prevention — the prizes that pull research forward, and the biomarkers that let us agree it worked. Start with his father, Dave.
Explore all 100+ experts