Holistic cancer care · MD-PhD
Oxford Longevity Project
Levels of Longevity Map Paul explores
Paul Ch’en is one of 100+ experts in the Live Beyond Project — a father & son quest for longevity.
Discover Live Beyond →Paul Ch’en reached the frontier of cancer care by an unusually long road. He was a biochemist first, then took a PhD in cancer immunology — working on cancer vaccines — did a postdoc at Oxford and Imperial, and only then went into medicine, training as an oncologist. He is, in his own shorthand, “MD-PhD.” Today he works with the Oxford Longevity Project.
What sets him apart is the holistic turn. In the transition into clinical work he also trained in cognitive behavioural therapy and Western acupuncture — deliberately, in the hope of helping cancer patients as whole people, at the interface between the hard science and everything the science leaves out.
His big-picture view belongs on the Bridge of Prevention. He suspects cancer will become steadily more treatable and manageable — pointing to how far we’ve already come with cancers like prostate. Underneath it sits the idea of tumour immunosurveillance: in a sense we all carry cancer all the time, held in check by the immune system. The task is to keep catching it and keep tipping that balance.
And he sees a deep symmetry. The way we manage the chronic illnesses of ageing, he argues, is, to a degree, no different from how we’re learning to manage cancer — as something to live alongside rather than simply defeat. It makes his work a win-win: what he learns from the longevity side he takes straight back to his day-to-day patients, and vice versa.
We spoke with Paul around the Oxford Longevity Project — a physician-scientist who has spent his career moving between the laboratory and the clinic, and who insists on treating the patient, not just the tumour. He is thoughtful and precise about what oncology can and can’t yet do, and quietly optimistic that cancer is becoming something more of us will live with, and through.
“To a degree, we all have cancer — it’s about tumour immunosurveillance. I suspect that cancer will become more treatable, more manageable, over time.”
— Paul Ch’en, Oxford
“What I learn from the healthspan and longevity side, and from the cancer side, I can easily take back to my own day-to-day patients. It’s a win-win.”
Paul Ch’en · OxfordI used to be a biochemist first, then a PhD in cancer immunology, a postdoc, and then medicine. So I’m MD-PhD.
Paul Ch’enI partly trained in cognitive behavioural therapy and Western acupuncture, in the hope of helping cancer patients — working in the interface.
Paul Ch’enI suspect cancer will become more treatable or manageable. Think how far we’ve come with prostate cancer.
Paul Ch’enThe way we manage the chronic illnesses of the aged population is, to a degree, no different from how we manage cancer.
Paul Ch’enThree ideas from the interface of cancer and longevity.
Biochemist, then cancer immunologist, then physician. That unusual sequence lets him hold the molecule and the patient in the same frame — the science of the disease and the human being living with it.
“I’m MD-PhD.”
Oxford · from the interviewHe trained in CBT and acupuncture on purpose, to meet cancer patients as whole people. Holistic care isn’t an add-on for him; it’s where he chose to work, at the interface science alone can’t reach.
“In the hope of helping cancer patients.”
Oxford · from the interviewCancer, increasingly, as a chronic illness to manage rather than only a battle to win — the same posture longevity medicine takes toward the diseases of ageing. What he learns on one side he carries to the other.
“More treatable, more manageable.”
Oxford · from the interviewPaul Ch’en is an MD-PhD oncologist with the Oxford Longevity Project. Find him on LinkedIn.
The video interview is coming. Recorded interviews go live after the launch of the film & series Live Beyond.
Paul Ch’en was filmed around the Oxford Longevity Project, 2024. Passages from that conversation:
Paul Ch’en“In terms of my background, I used to be a biochemist first. Then I did a PhD in cancer immunology — cancer vaccines, immunology — a postdoc for two years at Oxford and Imperial, and then I went into medicine. So I’m MD-PhD. My plan early on was to be a clinical or medical oncologist.”
Paul Ch’en“During that transition I partly trained in cognitive behavioural therapy and Western acupuncture, in the hope of helping cancer patients — working in the interface. I suspect cancer will become more treatable or manageable. With prostate cancer, for instance, we’ve come a long way. A lot of it is the idea of tumour immunosurveillance — we all have cancer, to a degree.”
Paul Ch’en“Having thought it through, the various managements, care and treatments we do with the chronic illnesses of the aged population are, to a degree, no different from the cancer stuff. It’s a bit of a win-win, because what I learn from the healthspan and longevity side, and from cancer, I can easily take back to my own day-to-day patients.”
More passages from the full interview will be published here.
Paul Ch’en sits on the Bridge of Prevention on the Longevity Map. Explore the rest of the cast on the People page.
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