Reproductive geneticist · University of Cambridge
Ovarian aging & the genetics of menopause
Levels of Longevity Map Staša explores
Staša Stanković is one of 100+ experts in the Live Beyond Project — a father & son quest for longevity.
Discover Live Beyond →Dr Staša Stanković is a reproductive geneticist with a PhD in Reproductive Genomics from the University of Cambridge. She studies why the ovary ages faster than any other organ — and how the genetic code behind it can be rewritten to extend women's fertility and healthspan.
Women's health, she says, sat "under the veil of taboo" for far too long — until 1993 women weren't even required in clinical trials. Working with the UK Biobank (around 200,000 women), her team mapped roughly 300 genetic determinants of ovarian aging and the age at which menopause begins.
Then they went further. By mimicking the DNA-repair genes carried by women with naturally later menopause, her team showed — for the first time — that you can extend reproductive lifespan and improve fertility (by around 25% in mice): the first proof that delaying menopause is possible.
Her bigger idea reframes the field: because the ovary ages two-to-five times faster than the rest of the body, it is a proxy for a woman's whole-body health — early menopause tracks with heart disease, diabetes and osteoporosis. Understand ovarian aging, she argues, and you learn about aging itself. She is now building the models — ovarian organoids — and a company to turn the science into medicine.
We filmed with Staša in Cambridge — the home of genetics and, at the Babraham Research Campus, a hub for aging science too. On camera and on a walk through the gardens, she explained why the ovary is the fastest-aging organ in the body, and how her lab is using genetics to rewrite the menopause clock. We picked up the thread again in London.
"When I'm thirty, my ovaries are almost geriatric. That's why this matters."
— Staša Stanković, in Cambridge
"Ovaries age almost five times faster than any other organ. So when I'm thirty, my ovaries are almost geriatric."
Staša Stanković · CambridgeWomen's health was under the veil of taboo for a very long time. Until 1993, women weren't even required in clinical trials.
Staša StankovićWe were the first to prove that by manipulating genes, we can extend reproductive lifespan, postpone menopause and improve fertility.
Staša StankovićThe ovary is a proxy for a woman's whole-body health — early menopause tracks with heart disease, diabetes and osteoporosis.
Staša StankovićScience, science, science. With knowledge, you can unlock so many opportunities.
Staša StankovićPulled from our conversation with Staša in Cambridge — the science, her approach, and her message to the next generation.
The ovary ages faster than any organ — and it's a window on the whole body. Understand ovarian aging, and you learn about aging itself.
"We have to stop thinking about ovarian aging as just fertility. It's an architect of overall healthspan."
Cambridge · 2024Two boats in parallel — use the knowledge we already have (lifestyle, biomarkers) while investing heavily in the science that's still missing.
"Get tested — know your hormone profile. Then education, education, education, and invest in the research."
Her approachWomen's health was neglected for too long; the fix starts with understanding your own body — and syncing biology with your plans.
"There's a huge gap in how we understand our own bodies. Educate yourself — and sync your biology with your life plans."
Cambridge · 2024The video interview is coming. Recorded interviews go live after the launch of the film & series Live Beyond.
Selected passages from our filmed conversation with Dr Staša Stanković — in Cambridge, on women's health, ovarian aging and the genetics of menopause.
Marek Piotrowski"What's the problem, and how do you want to solve it?"
Staša Stanković"Women's health was under the veil of taboo for a very long time. There wasn't much investment or research, so the basic biology of female reproductive health isn't understood — and until 1993 women weren't even required in clinical trials. Modern medicine was shaped around male physiology. If you don't have the basic knowledge, you can't innovate."
Staša Stanković"There's one organ that doesn't follow the trend of the others — the ovary. Ovaries age almost five times faster than any other organ. So when I'm thirty, my ovaries are almost geriatric — even before I use them for fertility, their function has started declining. We're born with a finite, non-renewable reserve of one to two million eggs, and it only ever gets smaller."
Staša Stanković"At Cambridge we studied more than half a million people in the UK Biobank — about 200,000 women. We identified around 300 genetic factors that determine the age you'll go through menopause. It's like a lottery you're born with. Now we can use that knowledge to predict a woman's fertility window, and to invent new therapeutics."
Staša Stanković"We took two DNA-repair genes carried by women with naturally later menopause and mimicked their effect in mice. We prolonged reproductive lifespan and increased fertility by about twenty-five percent — one of the first proofs that delaying menopause is a possibility. Those mice also responded far better to IVF."
Staša Stanković"We have to stop thinking about ovarian aging as just fertility. Because ovaries age two to five times faster than any other organ, we can use them as a proxy for a woman's overall health — even the brothers of women with early menopause tend to live shorter. Ovarian aging is an architect of overall healthspan."
Marek Piotrowski"What's your message to the younger generation of women?"
Staša Stanković"Education, education, education. There's a huge gap in how we understand our own bodies. Get tested — know your hormone profile. Be mindful of the environmental factors. And invest in science: with knowledge, you can unlock so many opportunities."
More passages from the full interview will be published here.
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