The 12 hallmarks of aging 10

Altered intercellular communication

Cells stop talking properly

A body is an organisation of forty trillion members, and it only works because they keep each other informed — by hormone, by immune signal, by nerve. With age the messages get noisier and the departments stop hearing one another.

Genomic instability01Telomere attrition02Epigenetic alterations03Loss of proteostasis04Disabled macroautophagy05Deregulated nutrient-sensing06Mitochondrial dysfunction07Cellular senescence08Stem cell exhaustion09Altered intercellular communication10Chronic inflammation11Dysbiosis12

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The twelve are not ours. They come from Hallmarks of aging: an expanding universe by Carlos López-Otín, Maria A. Blasco, Linda Partridge, Manuel Serrano and Guido Kroemer (Cell 186, 243–278, 2023), which added three to the nine the same five set out in The Hallmarks of Aging in 2013. Here we describe them to you — so you can understand them and feel them. And we filmed Guido Kroemer, one of the five, on the quest.

Cells stop talking properly.
Cells stop talking properly.
10

Altered intercellular communication

Cells stop talking properly

A body is an organisation of forty trillion members, and it only works because they keep each other informed — by hormone, by immune signal, by nerve. With age the messages get noisier and the departments stop hearing one another. Each starts optimising for itself, which is exactly how an organisation fails.

What you can dosomething you can do

This is where Kroemer’s point does the work: everything is connected, so improving any other entry on this page improves this one too. Directly, the levers are sleep, daylight early in the day, and keeping the background burn of number eleven down.

The science, in one sentence

The signalling between cells and between organs — hormonal, immune, neuronal — becomes noisier and less coordinated.

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