Deregulated nutrient-sensing
The fuel gauge stops reading true
Your body is always asking one question: is there food about? Insulin, mTOR, AMPK and the sirtuins are how it answers. Answer “plenty” every hour of every day and it never switches out of building mode into maintenance mode. Growth and repair are opposites, and ageing is partly the gauge jammed on full.
The most answerable thing on this whole page. Eat inside a shorter window. Keep the refined carbohydrate down. Stay strong and stay lean. Walk after a meal — ten minutes moves this more than most supplements do. Metformin has convincing mouse data and has not yet shown the same in healthy people.
The science, in one sentence
The network that reads how much food is available — insulin, mTOR, AMPK, the sirtuins — stops reporting accurately, so cells keep building when they should be clearing.