The twelve are not ours. They come from Hallmarks of aging: an expanding universe by Carlos López-Otín, Maria A. Blasco, Linda Partridge, Manuel Serrano and Guido Kroemer (Cell 186, 243–278, 2023), which added three to the nine the same five set out in The Hallmarks of Aging in 2013. Here we describe them to you — so you can understand them and feel them. And we filmed Guido Kroemer, one of the five, on the quest.

The gut garden loses variety.
The gut garden loses variety.
12

Dysbiosis

The gut garden loses variety

A couple of pounds of microbes live in your gut, and they are not passengers. They train your immune system and manufacture compounds your own cells cannot make. A young gut is a garden with forty species in it. An older one is often six, and the weeds are winning — while the wall between the garden and the bloodstream grows leakier.

What you can doa lot you can do

Variety beats any single superfood: thirty different plants across a week does more than any powder. Fibre feeds the good ones, fermented food adds to them. Take antibiotics when you genuinely need them and not when you do not. Probiotic capsules are sold a long way ahead of what the trials actually show.

The science, in one sentence

The gut’s microbial community loses diversity and shifts toward species that provoke inflammation, while the gut wall grows more permeable.

Back to all twelve

All twelve, one by one

The whole list on one page →