The twelve are not ours. They come from Hallmarks of aging: an expanding universe by Carlos López-Otín, Maria A. Blasco, Linda Partridge, Manuel Serrano and Guido Kroemer (Cell 186, 243–278, 2023), which added three to the nine the same five set out in The Hallmarks of Aging in 2013. Here we describe them to you — so you can understand them and feel them. And we filmed Guido Kroemer, one of the five, on the quest.

The DNA collects typos.
The DNA collects typos.
01

Genomic instability

The DNA collects typos

Every one of your cells holds the same three-billion-letter instruction book, and has to copy it perfectly, again and again, while sunlight and its own chemistry attack the pages. The proofreaders are astonishingly good. Ageing is what it looks like when the typos start arriving faster than they can be caught.

What you can dolittle you can do today

Less than anyone selling you a pill will admit. What is beyond argument is what causes the damage in the first place: tobacco, sunburn, heavy drinking. After that the useful move is not repair but detection — the scans and blood tests that find the consequence while it is still small.

The science, in one sentence

Damage builds up in the DNA faster than the repair machinery can clear it, and some of it becomes permanent.

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